metabolism_lecture_7 - Chapter 16: Citric Acid Cycle The 3...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 16: Citric Acid Cycle
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The 3 stages of cellular respiration: Oxidation of fatty acids, glucose, and some amino acids Production of Acetyl-CoA Stage 1 Stage 2 Stage 3 Oxidation of acetyl groups in citric acid cycle Abstraction of e - Funneling e -  through the respiratory chain reduces O 2 Oxidative phosphorylation, ATP production (respiration = aerobic phase of catabolism,    consumption of O 2 , production of CO 2 )
Background image of page 2
The 3 stages of cellular respiration: Oxidation of fatty acids, glucose, and some amino acids Stage 1 Stage 2 and 3 take place in  mitochondria : (respiration = aerobic phase of catabolism,    consumption of O 2 , production of CO 2 ) Mitochondrion:  Surrounded by  2 membranes  Inner membrane folds into  cristae   -> increases surface area for    enzymes of respiratory chain   CAC occurs in  the internal space,   the  mitochondrial matrix   Respiratory chain in inner membrane   -> radical and reactive oxygen species     are kept in confined space of the    mitochondrion “powerhouse” of  the cell Production of Acetyl-CoA
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Citric acid cycle (C AC )  or tricarboxylic acid (TCA) cycle Oxidation of an acetyl moiety to 2 x CO 2 Amino acids Porphyrins Glucose Amino acids (Stryer, 4 th edition) -3  ->  +4  : 7 e - +3  ->  +4  : 1 e - 8 “reduction equivalents” 3 x NADH/H +        + 1 x FADH 2 -3 +3 -3 +3 +4 Oxidation of  to 2 CO 2 CAC is an amphibolic pathway (catabolic and anabolic processes)
Background image of page 4
glycolysis fatty acids amino acids pyruvate C4 C4 C4 C4 C4 C5 C6 C6 acetyl-CoA (Stryer, 5. edition)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
(from glycolysis) Pyruvate dehydrogenase complex : 3 enzymes, 5 cofactors From the Nobel prize presentation speech: Coenzyme A is a compound with a rather small molecule, which, when united with the enzyme-protein, acquires the property  of binding acetic acid. Acetic acid is normally quite unreactive but when bound in this way it becomes labile and reactive and  represents the previously mystical 2-carbon compound which combines with a 4-carbon compound to form citric acid. A new 
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 25

metabolism_lecture_7 - Chapter 16: Citric Acid Cycle The 3...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online