BCH-7 Electron Transport _ Ox. Phos.

BCH-7 Electron Transport _ Ox. Phos. - Electron Transport...

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Electron Transport and Oxidative Phosphorylation The Eukaryotic mitochondrion is the site of the citric acid cycle, electron transport and oxidative phosphorylation. Under aerobic conditions, ATP is generated by electron transport along the inner membrane of the mitochondrion coupled with proton transport across the inner membrane. Oxygen is combined with protons to produce water. The production of ATP by oxidative phosphorylation (endergonic process) is separate from electron transport to oxygen (exergonic process) but they are tightly coupled to the synthesis of ATP by phosphorylation of ADP.
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Electron transport leads to pumping protons across the inner membrane of mitochondria creating a pH gradient (the basis for the coupling mechanism “Chemiosmotic Coupling”). NADH and FADH 2 (generated in glycolysis and the citric acid cycle) transfer electrons to oxygen via the lectron transport chain. This recycles them to electron transport chain. NAD + and FAD which can be used in various metabolic pathways. Oxidation-Reduction Potentials – The direction that the electrons flow in the reaction is determined by which direction would give the largest positive Δ E °´ .
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Electron Transport Organization – Four separate respiratory complexes can be isolated from the inner mitochondrial membrane. Complex 1 – NADH-CoQ oxidoreductase the electrons and protons are transferred to FMN then FMNH 2 transfers the electrons to Fe-S, but the protons are pumped through the inner membrane; en Fe ansfers the electrons to CoQ. The then Fe-S red transfers the electrons to CoQ. reaction is strongly endergonic and produces enough energy to drive the phosphorylation of ADP to ATP. Complex 2 – Succinate-CoQ reductase catalyzes the transfer of electrons from succinate to CoQ. Succinate transfers electrons to FAD, which transfers electrons to Fe-S ox which transfers electrons to CoQ.
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The process is endergonic, but not enough for ATP production. The electrons are passed from CoQ to a series of cytochromes, proteins that contain a heme group. The free energy of the different cytochromes are different and they are designated a, b
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BCH-7 Electron Transport _ Ox. Phos. - Electron Transport...

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