BCH-3 Glycolysis

BCH-3 Glycolysis - Glycolysis Glycolysis This is an...

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Unformatted text preview: Glycolysis Glycolysis This is an anaerobic process of glucose metabolism that yields two molecules of ATP. When it is coupled to the citric acid cycle and oxidative phosphorylation, it can yield energy equivalent of up to 32 molecules of ATP. This pathway is also called the Embden-Meyerhoff pathway. Pyruvate is formed from glucose and it can either be converted to ethanol or lactic acid, allowing for regeneration of reduced pyridine nucleotides. The individual steps in glycolysis are: phosphorylation Isomerization Phosphorylation Cleavage omerization Isomerization Oxidation transfer of phosphate group Isomerization dehydration, and transfer of phosphate group. Conversion of Glucose to Glyceradehyde-3- phosphate Converting glucose to glucose-6-phosphate is an endergonic reaction and it is pulled along by the hydrolysis of ATP. The net reaction is exergonic. Glucose + ATP Glucose-6-phosphate + ADP G o ' = -4 kcal mol-1 Take a look at table 17.1 to see how much more exergonic these reactions are at 37 C. This is carried out via hexokinase in the presence of Mg ++ . Glucose-6-phosphate inhibits the activity of hexokinase; this is a control point in the pathway. The Liver has glucokinase, which lowers blood glucose levels after one has eaten a meal. It requires a much higher substrate (glucose) level to achieve saturation than hexokinase does....
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This note was uploaded on 12/05/2009 for the course BCH 311 taught by Professor Howlett during the Fall '08 term at Rhode Island.

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BCH-3 Glycolysis - Glycolysis Glycolysis This is an...

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