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091009-BCH311 - BCH311 Introductory Biochemistry Fall 2009...

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BCH311 - Introductory Biochemistry, Fall 2009 Instructors: Niall Howlett, Ph.D., and Jay F. Sperry, Ph.D. Office: 379 CBLS, office hours M, W, F 11-12 Email: [email protected] Office Phone: 401-874-4306 TA: Alex Brown, Ph.D. Candidate Email: [email protected] Office: 239 CBLS Hours: M 2-3, Tu 4-5, W 6-7 Text: Biochemistry, 6th Edition, Campbell & Farrell, ISBN: 978-0-495-39041-1 Additional class material, including lecture notes, will be posted on Sakai 2099-BCH3110001 Introductory Biochemistry General Course Guidelines Please attend all the lectures Read ahead, prepare for class, read ahead Ask questions, in class, by email, etc Attend the tutorial sessions on a regular basis Study the sample exams in advance - will be posted on Sakai Please refrain from any sort of disruptive behavior
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Biofuels & Alternative energy sources
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Embryonic Stem Cell Research
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Embryonic Stem Cell Research
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Fanconi anemia
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Hutchinson-Gilford Progeria Syndrome An extremely rare accelerated aging disorder caused by de novo (‘new’) splice- site mutations in the LMNA gene
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Familial (Hereditary) Cancer
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Obesity Trends* Among U.S. Adults (2007) (*BMI 30, or ~30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% 30%
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H1N1 Influenza Virus 2009 H1N1, referred to as Swine flu early on, a new Influenza virus causing serious illness worldwide On June 11th, 2009, the World Health Organization officially recognized 2009 H1N1 as a global flu pandemic (last one was the Hong Kong Flu in 1968/1969)
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H1N1 Influenza Virus Influenza virus is an RNA virus of the family Orthomyxoviridae In humans common symptoms of influenza include fever, sore throat, muscle pain, headache, coughing etc Influenza viruses are often identified by their source of origin (swine, avian, equine) and their subtype (H3N2 or H1N1) H refers to hemagglutinin and N refers to neuraminidase, both antigenic viral glycoproteins that reside on the surface of the virus A glycoprotein is a protein covalently attached to an oligo (many) saccharide (sugar) chain The primary function of hemagglutinin is to recognize and bind to the surface of a target cell, and to facilitate viral entry
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H1N1 Influenza Virus A Replication A virion attaches to the host cell membrane via HA (hemagglutinin) and enters the cytoplasm by receptor-mediated endocytosis Viral ribonucleoproteins (vRNPs) are translocated into the nucleus where they are transcribed and replicated Newly synthesized viral mRNAs are translated into protein on ribosomes in the cytoplasm Viral proteins and newly synthesized vRNPs are assembled into virions and released
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What is Biochemistry? Definitions of biochemistry from the National Library of Medicine, Medline Plus i. Chemistry that deals with the chemical compounds and processes occurring in organisms ii. The chemical characteristics and reactions of a particular living system or biological substance Before we can begin to study the important concepts of biochemistry we first need to review:
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