091009-BCH311

091009-BCH311 - BCH311 - Introductory Biochemistry, Fall...

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Unformatted text preview: BCH311 - Introductory Biochemistry, Fall 2009 Instructors: Niall Howlett, Ph.D., and Jay F. Sperry, Ph.D. OfFce: 379 CBLS, of¡ce hours M, W, F 11-12 Email: [email protected] OfFce Phone: 401-874-4306 TA: Alex Brown, Ph.D. Candidate Email: [email protected] OfFce: 239 CBLS Hours: M 2-3, Tu 4-5, W 6-7 Text: Biochemistry, 6th Edition, Campbell & Farrell, ISBN: 978-0-495-39041-1 Additional class material, including lecture notes, will be posted on Sakai 2099-BCH3110001 Introductory Biochemistry General Course Guidelines • Please attend all the lectures • Read ahead, prepare for class, read ahead • Ask questions, in class, by email, etc • Attend the tutorial sessions on a regular basis • Study the sample exams in advance - will be posted on Sakai • Please refrain from any sort of disruptive behavior Biofuels & Alternative energy sources Embryonic Stem Cell Research Embryonic Stem Cell Research Fanconi anemia Hutchinson-Gilford Progeria Syndrome • An extremely rare accelerated aging disorder caused by de novo (‘new’) splice- site mutations in the LMNA gene Familial (Hereditary) Cancer Obesity Trends* Among U.S. Adults (2007) (*BMI ≥ 30, or ~30 lbs. overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥ 30% H1N1 Infuenza Virus • 2009 H1N1, reFerred to as Swine fu early on, a new Infuenza virus causing serious illness worldwide • On June 11th, 2009, the World Health Organization oF¡cially recognized 2009 H1N1 as a global fu pandemic (last one was the Hong Kong Flu in 1968/1969) H1N1 Infuenza Virus • Infuenza virus is an RNA virus oF the Family Orthomyxoviridae • In humans common symptoms oF infuenza include Fever, sore throat, muscle pain, headache, coughing etc • Infuenza viruses are oFten identi¡ed by their source oF origin (swine, avian, equine) and their subtype (H3N2 or H1N1) • H reFers to hemagglutinin and N reFers to neuraminidase, both antigenic viral glycoproteins that reside on the surFace oF the virus • A glycoprotein is a protein covalently attached to an oligo (many) saccharide (sugar) chain • The primary Function oF hemagglutinin is to recognize and bind to the surFace oF a target cell, and to Facilitate viral entry H1N1 Infuenza Virus A Replication • A virion attaches to the host cell membrane via HA (hemagglutinin) and enters the cytoplasm by receptor-mediated endocytosis • Viral ribonucleoproteins (vRNPs) are translocated into the nucleus where they are transcribed and replicated • Newly synthesized viral mRNAs are translated into protein on ribosomes in the cytoplasm • Viral proteins and newly synthesized vRNPs are assembled into virions and released What is Biochemistry?...
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This note was uploaded on 12/05/2009 for the course BCH 311 taught by Professor Howlett during the Fall '08 term at Rhode Island.

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091009-BCH311 - BCH311 - Introductory Biochemistry, Fall...

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