341lecture32nov30sakai

341lecture32nov30sakai - Cell Biology 341 Monday Today •...

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Unformatted text preview: Cell Biology 341 Monday, November 30, 2009 Today: • An example of Enzyme- coupled receptors: Receptor tyrosine kinases • Next: chapter 16 on the cytoskeleton • Exam 3 2008 and chapter 15 answers are posted on Sakai • Office hours this week are Thursday, Dec 3, from 1-3 pm • Exam Friday, Dec 4, covers chapters 12, 13, 14 and 15 (starting with slide 7 on October 30) • Find your #2 pencils Last lecture: • G s activates adenylyl cyclase → cAMP → cAMP-dependent protein kinase (PKA) → enzymes or CREB activator protein • Examples of G-proteins that regulate ion channels • Inositol phospholipid pathway: G q activates phospholipase C-β → IP 3 + DAG (stays in the membrane) • IP 3 → Ca ++ release from the ER • Ca ++ and DAG activate protein kinase C • Calmodulin binds 4 Ca 2+ → CaM kinases Calmodulin bends to twist around target proteins Figure 15-43 Each end domain binds two Ca 2+ The central α helix is flexible α helix of target protein, ex: CaM-kinase or NO synthase flexible (Part C, Figure 15-16) A third class of receptors:...
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This note was uploaded on 12/05/2009 for the course BIO 341 taught by Professor Noris during the Fall '09 term at Rhode Island.

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341lecture32nov30sakai - Cell Biology 341 Monday Today •...

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