341lecture32nov30sakai

341lecture32nov30sakai - Cell Biology 341 Last lecture...

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Cell Biology 341 Monday, November 30, 2009 Today: An example of Enzyme- coupled receptors: Receptor tyrosine kinases Next: chapter 16 on the cytoskeleton Exam 3 2008 and chapter 15 answers are posted on Sakai Office hours this week are Thursday, Dec 3, from 1-3 pm Exam Friday, Dec 4, covers chapters 12, 13, 14 and 15 (starting with slide 7 on October 30) Find your #2 pencils Last lecture: G s activates adenylyl cyclase cAMP cAMP-dependent protein kinase (PKA) enzymes or CREB activator protein Examples of G-proteins that regulate ion channels Inositol phospholipid pathway: G q activates phospholipase C-β IP 3 + DAG (stays in the membrane) IP 3 Ca ++ release from the ER Ca ++ and DAG activate protein kinase C Calmodulin binds 4 Ca 2+ CaM kinases
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Calmodulin bends to twist around target proteins Figure 15-43 Each end domain binds two Ca 2+ The central α helix is flexible α helix of target protein, ex: CaM-kinase or NO synthase flexible
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