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341lecture30nov23sakai - Cell Biology 341 Monday Today Last...

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Cell Biology 341 Monday, November 23, 2009 Today: NO → blood vessel dilation 3 types of plasma membrane receptors for hydrophilic signals Signal transduction pathways triggered by G- protein- coupled receptors Last lecture: concluded chapter 14 A Cu atom in the active site of the cytochrome oxidase complex passes 4 electrons to O 2 , reducing it to 2 H 2 O ATP synthase is a molecular turbine in which the transport of H + down its gradient causes rotation of F 0 and the γ subunit, driving conformational changes in F 1 that result in ATP synthesis by the β subunit See video 14.4 on your DVD on fluorescent ATP synthase as well as other videos for chapters 12-14 Began chapter 15: Different types of cells contains different mixtures of receptors for signals A signal may elicit different responses from different types of cells Hydrophobic signals cross the plasma membrane: steroid hormone receptors are transcriptional activators
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The role of nitric oxide (NO) in smooth muscle relaxation in blood vessel walls Nerve terminal releases acetylcholine → Ac activates NO synthase in endothelial cells NO diffuses to nearby smooth muscle cell → activates guanylyl cyclase → cGMP Figure 15-12 cGMP → relaxation of muscle cell → maximum blood flow Nitroglycerin → NO What other drug inhibits the phosphodiesterase that breaks down cGMP?
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