341lecture30nov23sakai - Cell Biology 341 Monday, November...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Cell Biology 341 Monday, November 23, 2009 Today: NO → blood vessel dilation 3 types of plasma membrane receptors for hydrophilic signals Signal transduction pathways triggered by G- protein- coupled receptors Last lecture: concluded chapter 14 A Cu atom in the active site of the cytochrome oxidase complex passes 4 electrons to O 2 , reducing it to 2 H 2 O ATP synthase is a molecular turbine in which the transport of H + down its gradient causes rotation of F 0 and the γ subunit, driving conformational changes in F 1 that result in ATP synthesis by the β subunit See video 14.4 on your DVD on fluorescent ATP synthase as well as other videos for chapters 12-14 Began chapter 15: Different types of cells contains different mixtures of receptors for signals A signal may elicit different responses from different types of cells Hydrophobic signals cross the plasma membrane: steroid hormone receptors are transcriptional activators
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
smooth muscle relaxation in blood vessel walls Nerve terminal releases acetylcholine → Ac activates NO synthase in endothelial cells NO diffuses to nearby smooth muscle cell → activates guanylyl cyclase → cGMP Figure 15-12 cGMP → relaxation of muscle cell → maximum blood flow Nitroglycerin → NO What other drug inhibits the phosphodiesterase that breaks down cGMP? the
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/05/2009 for the course BIO 341 taught by Professor Noris during the Fall '09 term at Rhode Island.

Page1 / 11

341lecture30nov23sakai - Cell Biology 341 Monday, November...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online