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341lecture24nov6sakai - Cell Biology 341 Last lecture...

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Cell Biology 341 Friday, November 6, 2009 Today: How proteins move through a translocator to enter the mitochondrion Sorting to the endoplasmic reticulum Synthesis of membrane proteins Chapter 12 reading: omit mitochondrial membrane proteins, chloroplasts, and peroxisomes in pages 717- 723, as well as pages 737- 745 Exam average = 69 Last lecture: sorting to the nucleus Nuclear proteins must pass through nuclear pore complexes nuclear localization signal nuclear import receptor nuclear pore complexes Ran-GTP in nucleus → cargo unloading; GTP hydrolysis in cytosol drives the active transport cycle Ran is a regulatory GTPase that also helps the nuclear envelope reform after mitosis Mitochondrial proteins are unfolded for translocation
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Protein import into mitochondria Figure 12-25 A receptor in the TOM complex in the outer membrane binds the signal sequence chaperone proteins in the matrix use ATP to help pull the protein across, and fold it unfolded The protein crosses both membranes at once TOM and TIM are translocator complexes in the membranes chaperones hydrolyze ATP membrane potential required
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