341lecture23nov2sakai

341lecture23nov2sakai - Cell Biology 341 Monday, November...

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Cell Biology 341 Monday, November 2, 2009 Today: • Sorting to the nucleus: nuclear localization signals • Nuclear proteins must pass through nuclear pore complexes (gated transport) Sorting to the Last lecture: began Chapter 12 on Protein Sorting • Acetylcholine binds its receptor on the muscle cell plasma membrane, which is a ligand-gated ion channel • This channel opens, allowing Na + to enter the muscle cell, and triggering an action potential that causes mitochondrion through a protein translocator • Exam Wednesday, Nov 4, covers chapters 7, 10 and 11, beginning on October 5 • Office hours: Tuesday 10 am-noon, 1-2 pm • Bring #2 pencils an action potential that causes contraction • Chapter 12: All nuclear-encoded proteins begin translation in the cytosol • A signal sequence is both necessary and sufficient for sorting to an organelle destination • No signal = remain in cytosol after translation
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Sorting signals are usually part of the protein sequence, up to 60 amino acids in length, called the signal sequence Some signal sequences are removed during protein sorting Not removed KDEL is not removed amino terminal Table 12-3 white = hydrophobic, red = (+), green = (-), blue = (-OH) Some signals (ER) are at the N-terminus; others are internal (nucleus) or at the C-terminus (return to ER, peroxisomes)
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Molecules enter and leave the nucleus through nuclear pore complexes (NPC) Multiple copies of about 30 nucleoporin proteins make Larger molecules, such as proteins, require a
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This note was uploaded on 12/05/2009 for the course BIO 341 taught by Professor Noris during the Fall '09 term at Rhode Island.

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341lecture23nov2sakai - Cell Biology 341 Monday, November...

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