341lecture15oct14sakai

341lecture15oct14sakai - Cell Biology 341 Last lecture:...

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Cell Biology 341 Weds., October 14, 2009 Today: More examples of eucaryotic gene regulation Exam average = 73 See the four videos on DNA-binding motifs on your DVD for chapter 7 Last lecture: Eucaryotic genes are regulated by multiple activators that bind enhancers within a large gene control region Eucaryotic activators increase the rate of assembly of the initiation complex for transcription by increasing the number of binding contacts The DNA may loop so that activators can interact with the initiation complex or Mediator The entire β globin gene cluster is activated by a Locus Control Region found far upstream Additional enhancer regions regulate the developmental expression of each globin gene in the cluster: the β globin gene has both upstream and downstream regulatory regions Steroid receptors are activators that turn on a group of genes
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A single activator may turn on a group of genes Figure 7-74 Other activators and Mediator may be involved, but the receptor is required to complete the complex The receptor is now an activator initiation complex see figure 7-16: a different type of zinc protein; is a dimer cytosol
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This note was uploaded on 12/05/2009 for the course BIO 341 taught by Professor Noris during the Fall '09 term at Rhode Island.

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341lecture15oct14sakai - Cell Biology 341 Last lecture:...

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