AP_R_PRINT

AP_R_PRINT - Action Potential Lectures What you will learn...

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Recording electrode 1 (e1) Recording electrode 2 (e2) Stimulating electrode 1 Spike initiation zone (SIZ) Action Potential Lectures III.A.1. Experimentally simplifying the question. What you will learn in these lectures 1. You will learn that although passive electrical properties are important for neural integration, they are not adequate to carry neural information over long distances. 2. You will learn what an action potential is. 3. You will learn the mechanisms behind action potential generation. 4. You will learn about the importance of channels in neural signaling and that the conformation of channels can be changed by influences such as the voltage across the cell membrane, ionic concentrations, and time. 5. You will once again see the importance of the chemical and electrical forces in neural signaling as these forms of stored energy are released during the action potential. 6. You will learn that the stored energy released during action potentials will allow neural signals to travel far reaching distances with little attenuation.
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Outline III. Action potentials (APs) III.A. Does the voltage change at the free nerve ending passively propagate to the spinal cord? III.A.1. Experimentally simplifying the question. III.A.2. Predicted results of experiments based on passive properties from previous lectures. III.A.3. Actual results of experiments III.A.4. Summary: action potentials (APs) are necessary to allow voltage signals to travel large distances without attenuation (Note: the purpose of APs is NOT speed; passive propagation is faster). III.B Overview of AP - Different phases of the action potential III.B.1. The rising phase of action potential III.B.2. The falling phase of action potential III.B.3. The undershoot of the action potential III.B.4. A thought problem III.C. Voltage gated channels and APs. III.C.1. Properties of voltage gated (VG) Na + channels. III.C.2. Properties of VG K + channels. III.C.3. Multiple meanings of the term threshold: be CAREFUL and explicit. III.C.4. Properties of action potentials that can be explained by VG-channels properties III.C.4.a. Refractory periods III.C.4.b. Propagation of APs. - AP travels like a burning fuse III.C.4.c. Summary of relationships of AP properties to VG channel properties. III.C.5. Diversity of channels III.C.6. Some techniques to study channels. III.D. Tying things together; relating the action potential lectures to the RMP and Passive lectures III.D.1. Relationship of passive electrical properties to myelin saltatory conduction III.D.1a. Myelin's effects on membrane resistance III.D.1.b. Myelin's effects on membrane capacitance III.D.2. Why are action potentials "active" when compared to the passive properties from previous lectures?
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time (msec) Voltage at e1 (mv) time (msec) time (msec) 0 10 20 Voltage at e2 (mv) -60 -20 20 Stimulating electrode Weak Stimulation Moderate Stimulation Strong Stimulation Stim -60 -20 20 0 10 20 0 10 20 0 10 20 0 10 20 0 10 20 e2 e1 SIZ III.A.2 & III.A.3.
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III.B Overview of AP - Different phases of the action potential
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AP_R_PRINT - Action Potential Lectures What you will learn...

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