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small_circ_Lecture

small_circ_Lecture - V.A.1 Properties that determine...

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a. Connectivity b. Synaptic Properties – these will be more clear later Accommodation, habituation, transmitter limitations Synaptic currents and voltage, or ion gating Variability in strength of synapses Multi-component PSPs Second messenger effects of metabotropic receptors Can be due to either multiple transmitters or More than one effect over time of the same xmitter c. Intrinsic Cellular Properties Endogenous spontaneous activity Some forms of post-inhibitory rebound V.A.1 Properties that determine circuit behavior
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A B A B time voltage voltage time Each line on the plots represent an action potential Excitatory neuron and synapse Monosynaptic Excitation: B has no spontaneous activity Inhibitory neuron and synapse V.A.2.a. Cell B has spontaneous activity
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