SynapXmit_Reader_print - Synaptic Transmission & Voltage...

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reader 1. You will learn that neurons are capable of transmitting electrical signals between each other. 2. You will learn about a historical experiment that demonstrated the importance of chemical messengers (called neurotransmitters) in neuronal communication. 3. You will learn that chemical communication between neurons takes place at chemical synapses. 4. You will learn the anatomy of the chemical synapse using Duckman. 5. You will learn the sequence of events leading to neurotransmitter release during chemical synaptic transmission 6. You will learn about various types of neurotransmitter and some distinguishing characteristics of each type. 7. You will learn about the two classes of receptor that bind neurotransmitter leading to a voltage change called a postsynaptic potential or PSP. 8. You will use some new techniques (i.e. inductive reasoning and voltage clamping) to determine whether a chemical synapse is excitatory or inhibitory. 9. While performing the voltage clamp technique, you will learn the definition of a reversal potential. 10. You will see that the reversal potential helps to determine whether a receptor is permeable to a single or multiple ions. 11. You will see that the reversal potential is beneficial when determining whether a synapse is inhibitory or excitatory. Electrically stimulate axon of free nerve ending Record from This spinal chord neuron IV.A.1. How does the somatosensory receptor communicate with a spinal cord neuron? time (msec) Voltage (mV) 70 -60 25 50 time (msec) 70 -60 25 50 -75 -65
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reader IV. Synaptic transmission Outline IV.A. Overview IV.A.1. How does the somatosensory receptor communicate with a spinal chord neuron IV.A.2. Do neurons communicate electrically or chemically? IV.A.2.a. Evidence for chemical: Von Lowei's experiments in 1929 IV.A.2.b. Evidence for electrical in some neurons: Furshpan and Potter 1959 IV.A.2.c. So some synapses are chemical and some are electrical. IV.B. Anatomy and structure of the chemical synapse IV.C. Synaptic Transmission - the presynaptic neuron sends a message IV.C.1. Sequence of events IV.C.2. Neurotransmitters IV.C.2.a. Properties of amino acid neurotransmitters IV.C.2.b. Properties of amine neurotransmitters IV.C.2.c. Properties of peptide neurotransmitters IV.C.2.d. Other types of neurotransmitters and neuro-modulators IV.D. Synaptic Transmission - the post-synaptic cell receives and transduces the message IV.D.1. Receptors IV.D.1.a. Properties of all neurotransmitter receptors IV.D.1.b. Properties of ligand gated receptors IV.D.1.c. Properties of metabotropic receptors IV.D.1.c.i. Structure of metabotropic receptors IV.D.1.c.ii. Metabotropic receptors can have complex far-reaching effects. IV.D.2. Determining the ions to which a receptor is permeable
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This note was uploaded on 12/06/2009 for the course NPB 100 taught by Professor Chapman during the Fall '08 term at UC Davis.

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SynapXmit_Reader_print - Synaptic Transmission & Voltage...

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