Lecture 12 - Two pyruvate molecules are formed per glucose...

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• Two pyruvate molecules are formed per glucose that enters glycolysis. Complete oxidation of pyruvate in the Krebs cycle produces 10 NADH, 2 FADH 2 and 4 ATP molecules ( Figure 9.16 ): C 6 H 12 O 6 + 10 NAD + + 2 FAD ! 6 CO 2 + 10 NADH + 2 FADH 2 + 4 ATP Electron Transport • The high-potential-energy electrons carried by NADH and FADH 2 participate in a series of redox reactions. These electrons are passed down an electron transport chain ( ETC ) in the inner mitochondrial membrane of eukaryotes (and in the cell membrane of prokaryotes) ( Figure 9.4c ). • At each step, electrons lose potential energy, and the energy released is used to pump protons across the membrane to form a strong electrochemical gradient. ATP synthase uses the proton gradient energy to phosphorylate ADP as protons go back across the membrane. • The final electron acceptor at the end of the electron transport chain is O 2 . • ATP synthase uses the proton gradient produced by the ETC to power ATP production by oxidative phosphorylation , which is linked to the oxidation of NADH and FADH 2 . Substrate-level phosphorylation
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This note was uploaded on 12/06/2009 for the course BIO 225 taught by Professor Pavgi during the Spring '08 term at University of Michigan.

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Lecture 12 - Two pyruvate molecules are formed per glucose...

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