Bio172W08Lec20CT - B io lo g y 1 7 2 L e c tu r e 2 0 : P r...

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1 Lecture 20: Prokaryotic Gene Regulation March 3, 2008 Today s Outline 1. Overview of gene expression 2. Control of Metabolism in E.coli by Operons - lac operon - trp operon Announcements This week in Discussion: Operon Ballet Biology 172 Gene Expression Regulating the amount of active gene product (protein) by: Control of gene expression at the level of transcription Control of at the level of translation Post-translational control Constitutive expression = gene product made continuously Regulated expression = gene product made on demand; expression can be induced or repressed Replication = produce exact copy of DNA for mitosis (cell division) or reproduction (pass to the next generation) Transcription = transcribe DNA code into RNA (uses same ‘language’ of nucleic acids) Translation = translate nucleic acid code into a sequence of amino acids (the primary structure of polypeptides) Post-translational modification = chemical modification
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Bio172W08Lec20CT - B io lo g y 1 7 2 L e c tu r e 2 0 : P r...

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