RNA Function and Structure Learning objectives

RNA Function and Structure Learning objectives - RNA...

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RNA Function and Structure Learning objectives 1. List and describe the various functions of RNA a. mRNA i. role 1. carrier of RNA (genetic information) from DNA in the nucleus to ribosomes in the cytosol ii. characteristics 1. a single mRNA molecule may code for one or several polypeptide chains 2. primarily single stranded 3. can base pair with itself iii. abundance 1. 5% iv. # of types 1. 100-10,000 nt in length v. Stability 1. from hours to days b. tRNA i. role 1. adapter between mRNA and ribosomes a. covalently linked to an amino acid at one end, they pair with the mRNA in such a way that amino acids are joined to a growing polypeptide in the correct sequence b. contains an anti-codon that is complementary to the mRNA codon to which it binds 2. characteristics a. largely double stranded via intrastrand base pairing b. participate in H-bonding with 2’ –OH c. ~75 nts in length 3. # of types a. 15% of all RNA 4. stability a. stable, no purpose in turnover c. rRNA i. role 1. components of ribosomes 2. structure and catalysis in ribosomes ii. characteristics 1. largely double stranded 2. participate in ribonuclear protein complexes 3. contain many methylated residues on base or 2’ –OH iii. abundance 1. 80% 2. 100-3000 nt in length iv. # of types
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1. prokaryotes a. 23s, 5s 2. eukaryotes a. 18s, 28s, 5.8s, 55s 3. very stable d. Overall i. RNA stabilization 1.
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RNA Function and Structure Learning objectives - RNA...

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