chromosome-structure - Recall centromere position can be...

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Chromosomal Variation Changes in chromosome structure Recall centromere position can be used to classify Different chromosome types Overview of structure changes in a chromosome Chromosome deletions • Types of deletion Terminal (end of chromosome) Interstitial (internal in the chromosome) • Deletion mapping – Deleted regions help fine-map genes pseudodominance -- expression of a recessive allele when placed over a deletion • Deletions are common in cancer cells
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Deletion mapping Deletions can be used To fine map genes pseudodominance -- expression of a recessive allele when placed over a deletion Deletions are common in cancer cells
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Duplications • Duplication of a chromosomal section • Bar-eye example in Drosophila • Generation by unequal crossing-over • Duplications lethal if two many genes are involved – Gene balance (correct stoichiometry ) is critical Unequal crossingover generates Bar variation
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Chromosomal pairing with Duplications • Chromosome paring with a
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This note was uploaded on 12/09/2009 for the course ECOL 320 taught by Professor Weinert during the Spring '07 term at University of Arizona- Tucson.

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chromosome-structure - Recall centromere position can be...

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