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assignment2 - CHM 3120 Assignment 1 1 a Show how you would...

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1 CHM 3120 Assignment 1 1. a) Show how you would make the syn isomer of the following and draw transition states to explain the selective formation of that isomer. OH How would you make the anti isomer? Explain your reasoning. 2. A Student trying to find the best method to synthesize a drug sample makes the following observation. Explain her results. OO H O H + Reagent LiAlH 4 LiBH(iBu) 3 3 99 : : 1 1 3. Propose a synthetic scheme to prepare the indicated isomer using the following sequence. Explain the selectivity. O CHO O OH How would you make the other ( syn ) isomer? Give two methods. 4. Predict the major product in the following reaction. Explain your choice.
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