LW_BCH4122_Lecture4_2009Sep edit

LW_BCH4122_Lecture4_2009Sep edit - Hierarchy of adult...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
(Immunity 2007;26:669) CFU-s, colony-forming unit-spleen; CMP, common myeloid progenitor; CLP, common lymphoid progenitor, MEP, megakaryocyte-erythroid progenitor; GMP, granulocyte-macrophage progenitor; BFU- E, burst-forming unit-erythroid; Meg, megakaryocyte; Eo, eosinophil; G, granulocyte; and M, macrophage. Hierarchy of adult hematopoiesis Hematopoiesis - after born
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Properties of Committed Progenitor Cells (Daughters of HSC) v Restricted to differentiate into only one or two lineages: i.e. a granulocyte- committed progenitor generate only granulocytes v Limited proliferation and self-renewal potential v Actively proliferating and thus sensitive to many S-phase-specific chemotherapeutic drugs v More frequency than HSCs, but still rare (1/1000 BM cells) v Similar to HSC, no distinguishing morphological features and examined by in vitro or in vivo functional assays, and surrogate surface markers Committed Progenitor Cells
Background image of page 2
Colony Formation Assays to Examine Committed Hematopoietic Progenitor Cells Marrow cells
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/11/2009 for the course BCH bch4122 taught by Professor Wang during the Spring '09 term at University of Ottawa.

Page1 / 6

LW_BCH4122_Lecture4_2009Sep edit - Hierarchy of adult...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online