LW_BCH4122_Lecture8_2009Sep - Lecture 8. Differentiation of...

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1 Lisheng WANG Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine Lecture 8. Differentiation of human embryonic stem cells into a given cell type for potential application current progress & Review previous Quiz The challenges for clinical application of hESC derivatives 1. Expansion of hESCs 2. Appropriate differentiation 3. Functional integration 4. Risk of teratoma or tumor formation 5. Immune rejection (Difficulty) Cell replacement therapy Drugs, growth factors, gene transfer, … Adult stem cells (or derived from hESCs, or iPS) replacement therapy Organ transplantation
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2 Paul J. Fairchild Immunological aspects in potential hESC therapy Patient-tailored hES (iPS) Differentiation Modified from MSC In vitro , hESC-derived neural stem cells give rise to multiple neural lineages (e.g. peripheral neurons, Schwann cells) In vivo , transplantation of these cells into the chick embryo and adult mouse hosts demonstrates survival, migration and differentiation compatible with neural tissues (functions?) Lee G. et al, Nature Biotechnology 2007; 25: 1468 Elkabetz Y. et al, GENES & DEVELOPMENT 2008; 22:152 165 Neural stem cells derived from hESCs
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This note was uploaded on 12/11/2009 for the course BCH bch4122 taught by Professor Wang during the Spring '09 term at University of Ottawa.

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LW_BCH4122_Lecture8_2009Sep - Lecture 8. Differentiation of...

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