LW-BCH4122-Lecture2_2009 Edit

LW-BCH4122-Lecture2_2009 Edit - Stem cell fate...

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Stem cell fate dedifferentiation
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Stem cell Nature 441, 1075-1079 (29 June 2006) Stem cell niche and environment Cell-cell contact, Cell-extracellular matrix contact Autocrine, paracrine and endocrine Structural and physical effects Neural regulation (endocrine)
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Clonality It is crucial to know whether a single cell is capable of developing an array of cell types (clonality), or whether multiple stem cell types, when grown together, are capable of forming multiple cell types. For instance, recent research has shown that a mixture of cells removed from fat tissue or umbilical cord blood are capable of developing into blood cells, bone cells, and perhaps others. However, Researchers have not shown that a single cell is responsible for giving rise to other cell types or, if so, what kind of cell it is.
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Symmtric or asymmtric cell division – stem cell strategies to accomplish dual task of self-renewal and generation of differentiated cells Orange: stem cells; Green: differentiated cells (Nature 2006; 441:1068- 1074)
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Sean J. Morrison & Judith Kimble
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This note was uploaded on 12/11/2009 for the course BCH bch4122 taught by Professor Wang during the Spring '09 term at University of Ottawa.

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LW-BCH4122-Lecture2_2009 Edit - Stem cell fate...

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