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Unformatted text preview: U NUSUAL M ANIFESTATIONS OF M ALIGNANCY Malignant Meningioma in a 3-Year-Old Girl I rfan Bayram, MD,* Nejmi Kiymaz, MD, Mustafa Harman, MD, and Serdar Ug ra, MD* A typical meningiomas constitute between 4.7% and 7.2% of meningiomas, whereas anaplastic (malignant) menin- giomas are less common, accounting for between 1.0% and 2.8% of meningiomas. 2 Meningiomas in the pediatric popu- lation are uncommon. Childhood cases account for approxi- mately 1.5% of all intracranial tumors. 3 We present a case of a meningioma exhibiting histo- logic features of frank malignancy in a 3-year-old girl. A 3-year-old girl presented to the hospital with coma and vomiting. Magnetic resonance imaging (MRI) revealed a huge (5 cm), heterogenous, right frontoparietotemporal intracranial mass, compression of the ipsilateral ventricle. Peripheral edema and central cystic areas was detected on T2-weighted image (Fig. 1). Histopathologic examination revealed a densely cellu- lar, extensively necrotic, highly vascularized, carcinoma sarcoma-like obviously malignant neoplasm composed of cells with pleomorphic, oval, pale nuclei, a high nucleus/ cytoplasm ratio, prominent nucleoli, high mitotic index (Fig. 2)....
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This note was uploaded on 12/11/2009 for the course UNT 123456 taught by Professor 123456 during the Spring '09 term at University of North Texas Health Science Center.
- Spring '09