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lecture_13 - 1 Lecture 13 Outline Structure of DNA DNA...

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1 Lecture 13 Outline Structure of DNA DNA dissociation DNA replication DNA polymerases and their exonuclase activities Replication origins Chromatin assembly Telomere replication Telomere cap
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2 STRUCTURE OF DNA Bases + deoxyribose + phosphate = nucleotides Chargaff's rule [A] = [T] [G] = [C] [PURINES] = [PYRIMIDINES] Double helix - J. Watson and F. Crick (1953) (M. Wilkins and R. Franklin) A pairs with T G pairs with C
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3 Detail of hydrogen bonding What is the structure of DNA fragment ends?
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4
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5 DNA dissociation and re-association profiles
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6 DNA REPLICATION Mathew Messelson and Franklin Stahl provided experimental evidence showing that DNA replicates semiconservatively: Each daughter DNA duplex contains one parental strand and one newly synthesized (antiparallel) strand.
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7 Mechanism of DNA replication All DNA polymerase synthesize DNA in the 5' 3’ direction. DNA is synthesized only by an extension of the 3' OH group on the of deoxyribose
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lecture_13 - 1 Lecture 13 Outline Structure of DNA DNA...

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