lecture_15

lecture_15 - Outline of lecture 15 Frameshift mutations and...

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Outline of lecture 15 Frameshift mutations and their suppression Nature of genetic code tRNAs Codon table Stop codons rRNAs and ribosomes Isoacepting tRNAs and wobble rules Translation i. Initiation ii. Elongation iii. Termination
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THE GENETIC CODE There are 20 essential amino acids and 4 bases 4 2 = 16 not enough to code for 20 aminoacids 4 3 = 64 too many to code for 20 amino acids How many letters are in the code ? rII gene of T4 phage mutagen proflavin - causes base deletions and insertions in the phage genome Frameshift forward mutations e.g. addition of a nucleotide Suppressor mutation: deletion of a nucleotide in the vicinity previous addition of nucleotide Original sequence THE FAT CAT ATE THE BIG RAT Addition (+) of A (frameshift) THE FAT A CA TAT E TH EBI GRA Deletion (-) of E (suppressor mutation) THE FAT ACA TAT THE BIG RAT Forward mutation Next mutation Suppression + - Y E S + + NO + +, + YES + +, +, + NO THE FAT CAT ATE THE BIG RAT… THE FAT
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lecture_15 - Outline of lecture 15 Frameshift mutations and...

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