lecture_214

lecture_214 - 1 Lecture 21 Outline of lecture 21...

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1 Lecture 21 Outline of lecture 21 Prokaryotic mobile elements Insertion sequences ( IS ) Transposons ( Tn ) R-plasmids Mechanisms of transposition: conservative and replicative Eukaryotic mobile elements RNA transposons and retroviruses DNA transposons
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2 MOBILE GENETIC ELEMENTS Insertion sequences (IS) : short DNA elements that can change position in the bacterial chromosome. Effects on genes : Interrupt coding sequences and inactivate the expression of the gene They may contain transcription and translation termination signals and block the expression of other genes in the operon Examples Insertion sequence No. copies in E. coli Length (bp) Inverted terminal repeats Duplication of host DNA (bp) IS1 5-8 chrom. 768 18/23 9 IS2 5 on chrom. 1 on F 1327 32/41 5 IS3 5 on chrom. 2 on F 1400 32/38 3 or 4 IS4 1 or 2 on chrom. 1400 16/18 11/12/13 IS contain inverted terminal repeats. Transposition generates a short direct repeat of the host DNA
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This note was uploaded on 12/13/2009 for the course BIS 101 taught by Professor Simonchan during the Fall '08 term at UC Davis.

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lecture_214 - 1 Lecture 21 Outline of lecture 21...

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