lecture_1

lecture_1 - 1 Outline of lecture 1. (1) (2) (3) Chromosome...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Outline of lecture 1. (1) Chromosome and its structure (2) First Mendel’s law (3) Second Mendel’s law
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Notes for Lecture 1 Eukaryotic chromosome: Terminus, telomere Centromere Chromatid DNA packaging A chromosome contains a single, uninterrupted DNA molecule. DNA in human chromosome 1 = 250 million bp (base pairs) 10 bp = 3.4 nm of DNA double helix. DNA molecule of human chromosome 1 is therefore 8.5 cm long. This molecule is packaged in chromosome that is about 10 μ m long. This example illustrates the need for complex packaging of DNA molecules in cells. Chromatin: DNA + HISTONES + NONHISTONE PROTEINS DNA is negatively charged. Histones are positively charged proteins for packaging DNA (rich in lysine and arginine, which are positively charged amino acids) Histones H1, H2A, H2B, H3, H4
Background image of page 2
3 Nucleosome : An octamer containing two molecules each of H2A, H2B, H3, and H4. The basic fiber of nucleoprotein is the 30 nm (solenoid) fiber
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 nm chromatin fiber = DNA wound on nucleosomes. About 145 bp of DNA is on a nucleosome and 20 to 100 bp links the neighboring nucleosomes, depending on organism and type of chromatin. 30 nm chromatin fiber : is a solenoid generated by coiling of the 10 nm fiber with the help of the H1 histone. A view inside the 30 nm chromatin fiber
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 11

lecture_1 - 1 Outline of lecture 1. (1) (2) (3) Chromosome...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online