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lecture_10 - Lecture 10 Outline: Mapping function Ordered...

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Lecture 10 Outline: Mapping function Ordered tetrad mapping Unordered tetrad mapping (Perkins formula) Colinearity of the genetic and physical maps MAPPING FUNCTION Remember: In every chiasma in a bivalent there is one crossover and only 50% of the for chromatids are recombined. If there was always a single crossover between the A and B loci, two of the four chromatids would be recombined; hence recombination between A and B would be 50%. The frequency of recombination between the A and B loci does not exceed 50% , even if the number of cross-overs in the A-B interval is higher than one.
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A and B . No. of chromatids involved Total no. of chromatids No. of chromatids showing recombination between A and B 2 (two-strand) 4 0 3 (three-strand) 4 2 3 (three-strand) 4 2 4 (four-strand) 4 4 Total 16 8 % recombination = 8/16 x 100 = 50% The greater is the distance between A and B, the more likely it is that two or more crossovers occur in the interval, and the more we
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This note was uploaded on 12/13/2009 for the course BIS 101 taught by Professor Simonchan during the Fall '08 term at UC Davis.

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lecture_10 - Lecture 10 Outline: Mapping function Ordered...

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