lecture_16

lecture_16 - Lecture 16 Outline of lecture 16 Operon...

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Lecture 16 Outline of lecture 16 Operon Positive and negative regulation of operons Negative regulation of the lac operon Allosteric effectors of regulatory proteins Cis - trans- dominance in merodiploids Positive regulation of the lac operon
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CONTROL OF GENE EXPRESSION PROKARYOTES Operon (Jacob & Monod) is a genetic unit of coordinate gene expression. THE lac OPERON The structure of the operon is: -galactosidase Lactose Transacetylase permease Represor Promoter Operator gene gene gene I P O Z Y A Z, Y, and A are transcribed into a single polycistronic (polygenic) mRNA. Gene I (outside of the operon) encodes a repressor protein.
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Factor not bound to DNA Factor bound to DNA
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Negative regulation of the lac operon LACTOSE (INDUCER) binds to the REPRESSOR protein. Lactose + repressor complex cannot bind to O. Induction is a relief of repression. Hence negative regulation
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Constitutive mutations : Mutations in the I gene. They affect not the activity of the produced enzyme but the
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This note was uploaded on 12/13/2009 for the course BIS 101 taught by Professor Simonchan during the Fall '08 term at UC Davis.

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lecture_16 - Lecture 16 Outline of lecture 16 Operon...

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