lecture_18_

lecture_18_ - C m pG C m p G C m pG G pC m G p C G p C m C...

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1 Lecture 18 Outline Epigenetics: definition Parental Imprinting: Maternal imprinting and paternal imprinting in mouse DNA methylation Histone methylation X-chromosome inactivation Inheritance of chromatin states
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2 Epigenetics Inheritance via altered chromatin states Parental imprinting Mouse Gene expression Maternal imprinting : paternal igf2 allele maternal igf2 allele yes no Paternal imprinting : paternal H19 allele maternal H19 allele no yes
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4 DNA methylation DNA-dependent methyl transferease hemimethylated fully methylated Replication DNA methylation
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Unformatted text preview: C m pG C m p G C m pG G pC m G p C G p C m C p G C m pG G p C m G p C m Histone methylation Histone H3 methyltransferease (HMTase) HMTase methylates the amino group on specific lysine residues on H3 histone 5 Gene dosage compensation : In the eutherian mammals : Female XX male XY X-chromosome inactivation in female Inactivated X chromosome: Barr body in the female nuclei Tortoise shell cat 6 In humans: Inactivated X chromosome: Lysine 9 of histone H3 methylated DNA of inactivated chromosome is hypermethylated 7...
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lecture_18_ - C m pG C m p G C m pG G pC m G p C G p C m C...

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