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lecture_23 - 1 Lecture 23 Outline of lecture 23 Aueuploidy:...

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1 Lecture 23 Outline of lecture 23 Aueuploidy: definitions Nullisomy Monosomy: Turner syndrome Trisomy: Klinefelter syndrome, Down syndrome, metafemale, metamale Aneuploidy in the human population Somatic aneuploidy: mosaicism Bilateral gynandromorphism
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2 ANEUPLOIDY Terminology: Count how many chromosomes of a homologous set are present in the cell. None = nulli somy One = mono somy Two = di somy Three = tri somy Four = tetra somy NULLISOMY is the absence of a homologous pair . Nullisomy is viable only in allopolyploids. Hexaploid wheat nullisomics for each of the 21 chromosome pairs
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3 MONOSOMY is the presence of a single homologue in a nucleus. For autosomes, monosomy is viable only in allopolyploids. Monosomy is usually viable for sex chromosomes. Monosomy originates via meiotic nondisjunction . In diploid organisms, meiotic nondisjunction results in the production of nullisomic and disomic gametes. Monosomy for sex chromosomes
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This note was uploaded on 12/13/2009 for the course BIS 101 taught by Professor Simonchan during the Fall '08 term at UC Davis.

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lecture_23 - 1 Lecture 23 Outline of lecture 23 Aueuploidy:...

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