Exam 1 Fall 2009 - Answers

Exam 1 Fall 2009 - Answers - Principles of Drug Action (BIO...

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Principles of Drug Action (BIO 365) Test #1 Name:_____________________________ September 25, 2009 Each of the 15 multiple choice questions is worth 0.8 marks out of 30 . 1. The drug diphenhydramine is marketed as Benadryl ® by the pharmaceutical company McNeil-PPC and as Nytol ® by GlaxoSmithKline. Which one of the following statements is TRUE ? A. Benadryl ® is a non-proprietary name and diphenhydramine is a proprietary name. B. Benadryl ® is a common name and diphenhydramine is a proprietary name. C. Benadryl ® is a proprietary name and diphenhydramine is a common name. D. Benadryl ® is a proprietary name and diphenhydramine is a non-proprietary name. E. Benadryl ® is a non-proprietary name and diphenhydramine is a common name. 2. As an oncologist treating a patient who has a tumour you decide to inject a toxic anticancer drug into an artery that supplies blood to the tumour. Which one of the following terms BEST describes this drug administration? It is A. sublingual B. topical C. percutaneous D. subcutaneous E. intravenous 3. The passive movements of drug molecules across lipid bilayers (biological membranes) depend on all of the following factors EXCEPT : A. drug concentration B. drug Pm/b C. drug polarity D. drug molecule size E. surface area of the absorbing membrane 4. Under saturating conditions anesthetic drug X has a water solubility of 50 mg/L and an oil solubility of 10 mg/L. Drug Y has a water solubility of 1 mg/L and an oil solubility of 5 mg/L. Which one of the following statements is FALSE ? A. The partition coefficient value of drug Y is greater than that of drug X. B. Drug X will cross the blood brain barrier more slowly than drug Y. C. If one drug has a greater absolute oil solubility than another it will also necessarily have a higher partition coefficient. D. Drug Y would be predicted to be a more potent anesthetic than drug X. E. Hydroxylating drugs X and Y would decrease their partition coefficient values. 5. Which one of the following statements is FALSE ? A. Clearance is directly related to the rate constant of elimination. B. Half-life is inversely related to the rate constant of elimination. C. If two drugs have the same rate constant of elimination, the drug with the lower volume of distribution will have the lower rate of clearance. D. Clearance is a first-order process. E. If two drugs have the same volume of distribution, the drug with the greater rate of clearance will have the longer half-life. 6. In the kidney most solute reabsorption occurs in A. The glomerulus.
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This note was uploaded on 12/14/2009 for the course BIO 51310 taught by Professor Sisson during the Spring '08 term at University of Texas at Austin.

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Exam 1 Fall 2009 - Answers - Principles of Drug Action (BIO...

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