BLG 311-LECTURE-WEEK 8-The Cell Cycle.pptx - BLG 311 CELL BIOLOGY WEEK 8 INTRODUCTION TO THE CELL CYCLE(Chapter 17 Dr Hossein Noyan Fall 2019 1 BLG311

BLG 311-LECTURE-WEEK 8-The Cell Cycle.pptx - BLG 311 CELL...

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BLG 311: CELL BIOLOGY WEEK 8 INTRODUCTION TO THE CELL CYCLE (Chapter 17) Dr. Hossein Noyan Fall 2019 1
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. 2014. Molecular Biology of the Cell. 6 th edition. W.W. Norton & Company Inc. BLG311 Required Text 2
Objectives Cell cycle phases Model systems to study cell cycle Checkpoints for cell cycle Control of the cell cycle (cyclins, cyclin-dependent kinases) Mitosis (with emphasis on the role of the cytoskeleton) Sister chromatid separation Telophase 3
Cell Cycle is a Cycle of Duplication and Division
Chromosome duplication occurs during S phase (S for DNA s ynthesis) Chromosome segregation and cell division occur in M phase (M for m itosis)
The Events of Eukaryotic Cell Division as Seen Under a Microscope
The Control of the Cell Cycle The cell-cycle control system governs cell-cycle progression at three major regulatory transitions: Start (or the restriction point) in late G1 The G2/M transition The metaphase- to-anaphase transition
Two Key Components of the Cell-cycle Control System Cdks are central components of the cell- cycle control system Cyclins are regulators of Cdk Without cyclin, Cdk is inactive.
Cyclin–cdk Complexes of the Cell-cycle Control System 1. G1/S-cyclins activate Cdks in late G1 and thereby help trigger progression through Start, resulting in a commitment to cell-cycle entry. 2. 2. S-cyclins bind Cdks soon after progression through Start and help stimulate chromosome duplication. S-cyclin levels remain elevated until mitosis, and these cyclins also contribute to the control of some early mitotic events. 3 . M-cyclins activate Cdks that stimulate entry into mitosis at the G2/M transition.
MITOSI S I can’t bear living with you anymore. I want the mitosis now!

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