Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. 2014. Molecular Biology of the Cell.6thedition. W.W. Norton & Company Inc.BLG311 Required Text2
Objectives•Cytoskeleton types and properties (actin, microtubules, intermediate filaments) •Static and dynamic functions of the cytoskeleton•Cytoskeletal filaments and protofilaments, polymerization and depolymerization•Treadmilling•Dynamic Instability•Motor Proteins (Myosins, Kinesins and Dyneins)•Muscle organization3
Some Features of Healthy Cells4Ability to organize themselves in spaceInteract mechanically with each otherInteract mechanically with their environmentTo be correctly shapedTo be physically robustProperly structured internallyFor some to be able to change their shape and move from place to placeTo be able to rearrange their internal components as they grow, divide and adapt to changing circumstances
The CytoskeletonThese spatial and mechanical functions depend on a remarkable system of filaments called the cytoskeleton.
These spatial and mechanical functions depend on a remarkablesystem of filaments called the cytoskeletonThe cytoskeleton is made of three families of protein filaments:
7Anthony L. Mescher - Junqueira’s Basic Histology Text and Atlas (2018, McGraw-Hill Education)
Actin Filaments•Determine the shape of the cell’s surface•Are necessary for whole-cell locomotion•Drive the force to help dividing one cell into two (cytokinesis)•Muscle contraction