BLG 311-LECTURE-WEEK 5-Intracellular Compartmentalization and Protein Sorting-STUDENT.pptx - BLG 311 CELL BIOLOGY WEEK 5 INTRACELLULAR AND PROTEIN

BLG 311-LECTURE-WEEK 5-Intracellular Compartmentalization and Protein Sorting-STUDENT.pptx

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BLG 311: CELL BIOLOGY WEEK 5 INTRACELLULAR COMPARTMENTALIZATION AND PROTEIN SORTING (Chapter 12) Dr. Hossein Noyan Fall 2019 1
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. 2014. Molecular Biology of the Cell. 6 th edition. W.W. Norton & Company Inc. BLG311 Required Text 2
Overview Compartmentalization of cells and organelles Signal sequences Transport between nucleus and cytoplasm Mitochondrial targeting and transport Endoplasmic Reticulum: protein folding and transport 3
Endoplasmic reticulum Plasma membrane 4
Endoplasmic reticulum Plasma membrane @plasmamembrane yo I’ve got that transporter you wanted. sending it to you now. #doingallthework #Ubetterthankme @EPretics sweet. I need it now. hurry. #transport4life #gettingsaltyuphere @plasmamembrane @EPretics hey I had to finish writing the address. Takes time. #checkurwork #aintnobodygottimeforthis @Golgi thanks brah! #friends4life #ERGIC #hopetheresnoBFAaround @EPretics @Golgi Got it. Sweet. Now we all get to survive. #suchhomeostasis #notreadytointernalize @plasmamembrane np. At least you’re not demanding like @lysosome #difficult @EPretics don’t hate. Who do you think takes care of your garbage #thinkaboutit 5
All Eukaryotic Cells Have the Same Basic Set of Membrane-enclosed Organelles Prokaryote cell
CELLS ARE COMPARTMENTALIZED 10
Evolutionary Origins May Help Explain the Topological Relationships of Organelles
Moving Between Different Compartments Using Proteins Gated Transport Protein Translocation Vesicle Transport 13
Proteins Can Move Between Compartments in Different Ways
Vesicular Transport
How Proteins Are Directed to the Correct Cell Address? Signal Sequences Sorting Receptors 16
During Cell Division New Organelles are not Made When a cell reproduces by division, it has to duplicate its organelles. Cells do this by incorporating new molecules into the existing organelles, thereby enlarging them. The enlarged organelles then divide and are distributed to the two daughter cells.

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