BLG 311-LECTURE-WEEK 1-Introduction to the cell-STUDENT.pptx - BLG 311 CELL BIOLOGY WEEK 1 INTRODUCTION TO THE CELL AND CELL BIOLOGY Dr Hossein Noyan 1

BLG 311-LECTURE-WEEK 1-Introduction to the...

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BLG 311: CELL BIOLOGY WEEK 1 INTRODUCTION TO THE CELL AND CELL BIOLOGY Dr. Hossein Noyan Fall 2019 1
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P. 2014. Molecular Biology of the Cell. 6 th edition. W.W. Norton & Company Inc. BLG311 Required Text 2
Cells and Cell Biology All living things are made of cells. Cell biology is the study of the structure, function, and behavior of cells. Despite their apparent diversity, living things are fundamentally similar inside. 3
Heredity and Life Each species is different, and each reproduces itself faithfully, yielding progeny that belong to the same species. Heredity is central to the definition of life. The whole organism has been generated by cell divisions from a single cell. The single cell is the vehicle for all of the hereditary information that defines each species. 4
Hereditary Information is Stored in DNA Cellular hereditary information is stored in a linear molecule called DNA 5
Cells vs. Computers Living cells like computers store information. 6
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DNA and its Building Block All Cells Replicate Their Hereditary Information by Templated Polymerization. 8
DNA Replication (Synthesis) 9
All Cells Transcribe Portions of Their Hereditary Information into the Same Intermediary Form: RNA el-mallick/posts/29027-and-they-lived-happily-ever-after-a-mic robial-fairy-tale-of-dna-and-rna
Inserting Human DNA into a Bacterium We can take a piece of DNA from a human cell and insert it into a bacterium, or a piece of bacterial DNA and insert it into a human cell , and the information will be successfully read, interpreted, and copied. e.html 11
Transcription
Main types of RNA 1.mRNA: messenger RNA: intermediate encoding the protein sequence Each specific amino acid is represented by a specific set of three-nucleotide sequences = codons These codons are translated into protein by the ribosome 2.tRNA: transfer RNA An intermediate that matches the mRNA codon to the corresponding amino acid 3. rRNA: ribosomal RNA Structural RNA molecules that build the ribosome along with ribosomal proteins 13
Figure 1-10a Molecular Biology of the Cell , Fifth Edition (© Garland Science 2008) TRANSLATION: Ribosomes read mRNA into protein 14
Proteins as Catalysts All cells use proteins as catalysts. 15
Life as an Autocatalytic Process

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