L-1819-CV03.pptx - PHYL 1010 DEHY BLOCK YA 2853 Cardiovascular Physiology 3 Contraction Cardiac Cycle 4 Cardiovascular Physiology Endocrine Physiology 5

L-1819-CV03.pptx - PHYL 1010 DEHY BLOCK YA 2853...

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PHYL 1010DEHY 2853Endocrine PhysiologyCardiovascular Physiology123BLOCK YA:Cardiovascular Physiology 3 Contraction & Cardiac Cycle456
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Skills EC Coupling & Relaxation Cardiac CycleCardiac EfficiencyEDV, ESV, SV, CO, VRpreload, contractility, afterload
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Excitation – Contraction (EC)Couplingaction potential in neighbouring cell sends positive ionsthrough gap junctioncell membrane depolarized to thresholdaction potential initiatedaction potential spreads along cellmembrane & into T-tubuleswhenvoltage-gated Ca2+ channels open,Ca2+ enters cell & induces the release of Ca2+ from the SR via calcium release channelsCa2+ initiate crossbridge cyclecell contractsSilverthorn Figure 14.10Calcium InducedCalcium ReleaseCICR
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RELAXATIONMembrane repolarizesCa2+channels closeCa2+ dissociates from troponinmost Ca2+ pumped back into SRmost Ca2+ leaving cell goes via Na+/Ca2+ exchangersome Ca2+ pumped out of cellNa+/K+ pump maintains membrane potentialSilverthorn Figure 14.10
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