Final exam 06

Final exam 06 - NAME You may pick up your exam from...

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NAME_________________________ You may pick up your exam from Professor Sia next semester or, if you wish, we will put your exam in the hall (next semester) near Professor Sia's office (HH 326B). Please put my exam in the hall _________. BIO 198 GENETICS FINAL EXAM December 18, 2006 200 Points 3 hours (~1.1 Points/Min) Instructions : 1) Write your name at the top of each page. 2) Answer questions, in the space provided, using ink . If you change an answer, clearly cross out the information you do not wish to be considered by the graders. Do NOT use white-out. 3) Please write neatly and be concise. Use pictures or diagrams if appropriate. 1)_______/11 7)_______/11 2)_______/18 8)_______/10 3)_______/13 9)_______/18 4)_______/27 10)_______/12 5)_______/36 11)_______/15 6)_______/14 12)_______/15 TOTAL________/200 1
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NAME_________________________ 1. (11 points) Below is the pedigree of a family with several members exhibiting a rare genetic disorder. a. (3 points) What is the likely mode of inheritance for the disorder shown above? b. (5 points) Assign genotypes to all of the individuals in the pedigree in generation II. c. (3 points) The individual labeled IIIa has asked you the probability that he will have a child with the disorder. Based on your answer in A, what will you tell him? 2
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NAME_________________________ 2. (18 points)    a. Draw a replication fork.  On this figure, indicate leading and lagging strands, 5’ and 3’ ends, and  indicate the following proteins  (in a few words, describe the function of each protein in the following  list): i.  DNA Polymerase III ii.   β -clamp iii.  ligase iv.  DNA Polymerase I v.  DnaB (helicase) vi. DnaG (primase) vii. Ssb 3
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NAME_________________________ 3. (13 points) You have obtained the following short DNA sequence (only one strand shown) from the middle of a bacterial gene. It is known that transcription of this sequence proceeds from right to left (i.e. the promoter is far to the right). 5’-TGCTAGCTAACT-3’ a. (3 points) What is the mRNA sequence (drawn 5’ to 3’) encoded by this part of the gene? b. (6 points) What peptide sequence is present in the protein encoded by this gene? Label the amino and carboxyl ends of the peptide. c. (4 points) If you know a codon sequence, can you determine the exact sequence of the tRNA anticodon? Explain. 4 QuickTimeª and a GIF decompressor are needed to see this picture.
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NAME_________________________ 4. (27 points) Comparison of the bacterial BER AP endonuclease sequence with the database of yeast proteins reveals the presence of a predicted protein with homology to the bacterial enzyme. a.
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This note was uploaded on 12/16/2009 for the course PHARM 121 taught by Professor Bob during the Spring '09 term at Rochester.

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Final exam 06 - NAME You may pick up your exam from...

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