1999 6 - C{IV ‘é’ A second messenger that is formed...

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Unformatted text preview: C? {IV \. ‘é’. A second messenger that is formed inside cells from adenosine triphosphate is ' Q. a) guanosine diphosphate g b adenine diphosphate (J 6i) cyclic adenosine monophosphate d) cyclic guanosine monophosphate e) guanosine triphosphate ionic (electrostatic) bond @HS'WW , hydrogen bond 41%" N , _\ c_hydrophobic HUS b d) ion reinforced hydrogen bond ’0 Ca V1) DEW“ Jahionic bond with Y= NH3 + ”W ”29. The majority of drugs, especially phannacodynamic drugs, form reversible non- covalent bonds with their receptors. Such bonds are generally weak (a few Kcalslmole each). However, some drugs bind very strongly to their receptors because they fom'I _ 6.6g: ~ ' . ' a)lan ionic bond figf \M. b) an Ion-reInforced hydrogen bond .. (aka hydrophobic bond d) several reversible bonds<== fife hydrogen bond é. in a site-specific labeling experiment designed to identify a binding site amino acid of a receptor, a worker reacted a selective alkylating [email protected]) with a receptor R hydrolyzed the alkylated receptor A—R, isolated the arriino acid ahd small peptides that were alkylated and identitied\§h e following 2 substances (among others): histIdIneL—A) and H2 N— histidineog) FJSerine—alanine-MECOOH The previously determined primary amino acid sequence of the receptor indicated the following amino acid sequences: H N histidine(21)—[email protected](23)—alanine(24)— COOH i-i2 N- alanine(56)— -histidine(57)-se_rine(58)~alanine(59)- -lysine-COOH H:N- -|ysine(85)- -serine(86)—alanine(87)- a—Ianine(88)— -COOH An amino acid in the receptor binding site is, @histidine( (22)”! b) histidine(57)r Veieerine (23) (O‘T'serinews) e) histidine(21) ...
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