2000 3 - 11 Application of recombinant DNA technology leads...

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Unformatted text preview: 11. Application of recombinant DNA technology leads to drugs that are difficult to synthesize and formulate. They mainly represent the following type of compounds: a) amino acids d) oligonucleotides b) proteins e) carbohydrates c) steroids 12. The majority of drugs used today were acquired by application of organic chemical synthesis. a) TRUE b) FALSE 13. Codeine is an analgesic (pain reliever) and an antitussive (cough suppressant). The development of dextromethorphan as a nonprescription an antitussive was based on the structure of codeine. In terms of the synthesis and development of dextromethorphan as an antitussive, codeine sewed as OH CH3 ‘3“3 CH3 DCHs codeine dextromethorphan a) a lead compound b) a target compound 0) a starting material d) a prodrug e) all of the above 14. Select an isosteric replacement for an H-atom on the aromatic ring of ephedrine, a decongestant commonly found in nonprescription cold preparations: CH3 H "( CH3 OH a) -F b) -l C) -CH3 d) —NH2 e) -N02 The van der Waals radius of H and F is 1.20 Angstrom, and 1.35 Angstrom, respectfully. All the rest are larger (l is 2.1 A, CH3 is 2.0 A, etc.) 15. In terms of drug design, structure-activity relationships (SARs) are used by medicinal chemists to ...
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