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2000 7 - ,3 the 2-amino group of guanine b N-T group of...

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Unformatted text preview: ,3) the 2-amino group of guanine b) N-T group of guanine c) the 4-amino group of cytosine d) the B-amino group of adenine e) N—3 of thymine 29. Sodium chloramphenicol monosuccinate (CAPS) is NHCOCHCI2 O H o 9¢ H0 3 N02 a) a prodrug ,, 2i ,_ b) suitable for the preparation of concentrated aqueous (intravenous) dosage forms c) activated in vivo (in the body) by hydrolysis catalyzed by an esterase d) a & b e) a, b & c 30. What is the percentage of the acid form of nicotine (nicotinium ion, fiéNH’w at an intestinal pH of 6, ifthe nicotinium ion’s pKEl = 8? '5 a) 99.9% i' , \ b) 99 % _ ,A~"'“' c) 90.9% x l H"- e "1/ m“, d) 9.1 % m CH3 . e) 0.99% PH = PKa + IOQIA'MHAJ = PKa + IogIBMBH’] logIBWJIIB] =‘pKa - pH = 2 [BH’JIIB] = 100 [am/(tan? + [31) = 99 31. X.Q. was admitted to hospital following ingestion of an overdose of phenobarbital, 0 CH3 HN 0% N O H ...
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