2001 7 #1A - @1 Which of the following drugs has...

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Unformatted text preview: @1/ Which of the following drugs has Maine—ring as part of its structure? a) 5-FU K b) pyrimethamine O c) trimethoprim d) pentostatin giaallopurinol 34. Which of the 'following physical or chemical properties oiurig‘a‘cid is a causative féFE’LHngutz ./ _ b) acidity b) metabolic stability 0) chemical reactivity 3x (332) poor water solubility e) poor lipid solubility 35. All but 9 of the following drugs are converted enzymaticallyto one or more intra- cellular metabolitesthat are as active or more active. Which is the one that does not? a) 5—FU A b) L-dopa .., Q/ o) allopurinols d) methotrexatew @ Captopril —« 36. Trifluoromethyl ketones fotmwcoyalentlyflbound, inactive complexes reversibly at the active site of elastase (see below). What is the chemicaLname of these adggcts? Enz-Ser‘ Ha hemiketal OK, ) hemiacetal . c) trifluoromethyl ester d) trifluoromethyl ether 9) Schiff—base 37. Smoking-induced oxidation of a methionine residuein alpha-717 antitrypsin, a natural regulator of elastase, to the corresponding sulfoxide (S-oxide) has been implicated in [the pathogenesis of which one of the following diseases? a) hypertension b) diabetes & c) gout 549T emphysema e) lung cancer ...
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