2001 8 #1A - rofolate reductase(DHFR_i_nh_i_bitor_s...

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Unformatted text preview: rofolate reductase (DHFR)-_i_nh_i_bitor_s trimethoprim 38. Selective toxicities of the dihyd q W e. resperztiyijigases-afizfliaglag and pyrimethamine to bacteria and the malaria parasit “to which of the following? ' a) differencesin target cell structure b) unique target . c) unique biosynthetic pathway 0 d) different mechanisms of action fiaspecies differences in target protein structure erQlate ,redugtase inhibitors 39. What common structural component of the dihyd pronsiblafprnthatighfttifig‘ifig of mBJhDHGJ—‘atei tflm§»1fl99flm..‘,and.,ml,rim§t_b§mig§ ,‘isres these Waste the. enamel” a) benzene ring , b) the aromatic protons on the benzene ring C &m' ‘2,4-diaminopyrimidine~ - d) conjugated double bonds e) CHa-group 40. Ergosterol can serveas a unique target of drugvactioncin whichof the following .ngénisms? "f a) Gram-positive bacteria C b) Gram—negative bacteria fungi d) malaria parasite e) viruses 41. Inhibition of DHFR by methotrezgatfieblgcfismthg synthesis of which of the following ”cellular components? """" W ‘ “" a) proteins A?) DNA \1 c) polySaccharides 3 d) phospholipids e) amino acids 42. Methotrexate can enter the cell primarily by which one of the following mechanisms? ’“hm ~ i ., a)/_passive diffusion " b)" facilitated diffusion ‘ d c) an energy independent pathway' ' (3‘3? carrier mediated active transport— e) endocytosis 43. Boylyglutamylation of methotrexate may increase the, cellular retention of the drug. Is this statement true .Ql' raise? ” ' TRUE Cb b) FALSE ...
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