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2002 5 #1C - 23 The more lipophilic the drug the easier it...

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Unformatted text preview: 23, The more lipophilic the drug, the easier it can cross the blood-brain barrier (BBB). is this statement TRUE or FALSE? "ETRUE FALSE 24. Which ofthe following statements about drug metabolism is FALSE? l/a/) it is carried out mainly in the liver b) it is localized in the microsomal subcellular fraction c) it makes drugs less lipophilic a“ it makes drugs more water soluble V‘ it makes drugs more easily reabsorbed by the kidneys 25. Which of the following statement about cytochrome P450 is FALSE? a): it is an enzyme system )2!) it catalyzes the oxidation of drugs " , it contains iron at the active site t 3 it converts drugs to a less polar form ) it is localized in the endoplasmic reticulum 26. Which one of the following statements is correct about glucuronide and sulfate metabolites? readily cross the blood4brain-barrier (BBB) are easily reabsorbed by the kidneys ’ are not excreted into the urine to any significant extent " are products of conjugation reactions exist mostly as cations in body fluids 27 What property of a drug is revealed by the Ames' test? a) lipophilicity b CNS toxicity 2 carcinogenicity , ability to cross the blood-brain barrier (BBB) )2) optical rotation 28. Some environmental carcinogens undergo metabolism to chemically reactive epoxide derivatives, which can be detoxified by conjugation with which of the following: a) glycine glucose glutathlone d) gluouronic acid e) glutamine ...
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