Unformatted text preview: cule can undergo metabolism at multiple sites. 35. The analgesic meperidine mole
onsible for formation of Which one of the following reactions CANNOT be resp meperidine metabolites in the body?
OCZH5 _ CH3_N \
o Meperidine a) hydrolysis
b) hydroxylation c , N-dealkylation
e conjugation of phenolic metabolites 38. Which one of the following metabolites CANNOTform from the antidepressant
imipramine (Drug-N(CH3)2) by oxidative dealkylation ? 0 t /
KLMCHS \N» “RON?
Imipramine CH3 , ‘2‘
a) Drug-NHz , l \ 3“
p) Drug-NHCH3 ,0:9 N\ 1‘?‘
‘c Drug-NHCHZOH N, )3 d3 bx.
@ Drug-NCHO ,U/en HI 0“
" e) Drug-N(CH3)CH20H ‘4
\f3% 37. Chloramphenicoi monosuccinate (succinic acid: HOOCCHZCHZCOOH) is a
prodrug form of the antibiotic, which, compared to the parent drug has a decreased water solubility b; has an improved taste c” can cross the blood brain barrier easier 3 has a lower molecular weight
@, is more suitable for intravenous (IV) administration 38. Cytochrome P450-mediated oxidation of the methyl group of the antidiabetic
mide can result in the formation of ALL BUT ONE of the following functional tolbuta
, o _®' Q %-—NH—CO—NH/\/\
\ o toibutamlde
‘a) -COOH , J . O_\
6 —CH20H t r 0 Q \: _
t —COOCH3 . a Q \ \. C!
s) -CH0 ' \ 0 , Q /C/ l
\e)‘-CQO' , .7 MC, \ .l /O ...
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- Spring '08