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2003 4 - 7 17 Aspirin is less readily absorbed from the...

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Unformatted text preview: 7 17. Aspirin is less readily absorbed from the stomach, than it is reabsorbed by the kidneys. Is this statement TRUE or FALSE? )7 it is carried out mainly in the liver )3) it is localized in the endoplasmic reticulum c it makes drugs less lipid soluble it makes drugs less water soluble -’ ,40’ it makes drugs less easily reabsorbed by the kidneys 19. Which of the following statement about GM //a) it is a mixed-function oxidase ‘ )5 it is responsible for the hydroxylation of dmgs , it contains a heme at the active site M @‘t converts drugs to a more - Wm it is localized in the microsomal fraction of the liver //-\ V \ 20. ich one of the following statements i Nafiorrect about glucuronide D me elites? IFMa’Li/L, M if they have difficulty crossing the blood-brain-barrier (BBB) \[ Q, by they cannot easily be reabsorbed by the kidneys or @f (g are easily excreted into the urine ‘i/ 5 their formation requires the ooenzyme PAPS 1' Q) they exist mostly as anionsin body fluids 21. What property of a drug is revealed by the Ames' test? a) stability b) liver toxicity @carcinogenicity d) susceptibility to oxidative decomposition e) susceptibility to hydrolytic decomposition /“\ fl/ @Some environmental carcinogens undergo metabolism to chemiglly Leactive u: Natives, which can be detoxified by coniugation [with glutgmigne. Which of the / following reactive groups are involyeg in this coniugation reaction? ' foal! Zeal to ECU/4L ...
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