2003 8 - i5 40 Which one of the followmg Is NQTIIkely to be...

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Unformatted text preview: i5 40. Which one of the followmg Is NQTIIkely to be affected by th chiralIty of a dru : passive diffusion across the blood-brain-barrier (BBB) M nature of the pharmacological response /cT recognition of the drug by its target d) CYP450-mediated hydroxylation 94) active transport 41 ALL B T ONE of the following amino acid residues in proteins may become osphorylate as part of a regulatory mechanIsm: '9 serine (Ser) @threonine (Thr) @ tyrosine (Tyr) histidine (His e) asparagine (Asn) 42. Which one of the following therapeutic agents are least likegy to be produced by recombinant DNA technologylw lfampin 137 growth hormone c) tissue plasminogen inactivator (TPA) ,d)’ {3- -interferon ,e‘)’ erythropoietin 43. Which one of the following functional groups 5 NOTs ceptible to metabolism by hydrolysis? h/;: a) amide b) ester ,c') lactam © 69 lactone “~ ketone /C \ 44. The discovery of sulfonamides is attributed to which of the following scientists? a) Fleming b) Florey Domagk d Ehrlich e) Waksman 45. Which one of the following drugs does NOT requir‘ metabolic activation? a) sulindac / IJQTFQC‘DWG \ )cy‘clgghos mide Q 492:. ine hrineflflgfifj 16 a "mpicillin ...
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