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2003 9 a - 46 The reactive metabolite of the carcinogenic...

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Unformatted text preview: 46. The reactive metabolite of the carcinogenic benzo(a)pyrene a component of cigarette smoke alkylates DNA at which of the foliow' ine? -NH2 A)“ N-1 A N-3 d) N-7 ’9')’ N—Q DNA 47. Which of the followingguSstituents an a flgon a m xerts the stron est electron withdrawingEinductIve effect? WWW d) -Br e) —| 48. Which of the following enzymes is the target of captopril? ., a) xanthine oxidase b) thiopurine methyltransferase (TMPT) c) phenylalanine hydroxylase d) adenosine deaminase @angiotensin converting enzyme (ACE) CDT he metabolic activation of cyclophosphamide hwolves ALL BUT ONE of the w Ing. Cl W me... o ,. a) hydroxylation of 0-4 : 0\ g N/\/ [l' 2 N (V ring opening 0 formation of phosphoramide mustard d) elimination of acrolein 4 - - - “\_ c clo hos hamide . Increas c at the N-atorry y p p C/ (5 5).00mplete hydrolysis andiN-demethylation of cocaine yields ALL BUT ONE of the °‘”'“9 0 OCH3 a) formaldehyde / b a free hydroxyl on the drug CH3 free ketone carbonyl on the drug @ benzoic: acid a» @methanol cocaine 0 ...
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