Unformatted text preview: 46. The reactive metabolite of the carcinogenic benzo(a)pyrene a component of cigarette smoke alkylates DNA at which of the foliow' ine?
d) N-7 ’9')’ N—Q DNA
47. Which of the followingguSstituents an a ﬂgon a m xerts the stron est electron withdrawingEinductIve effect?
WWW d) -Br
e) —| 48. Which of the following enzymes is the target of captopril?
a) xanthine oxidase
b) thiopurine methyltransferase (TMPT)
c) phenylalanine hydroxylase
d) adenosine deaminase
@angiotensin converting enzyme (ACE) CDT he metabolic activation of cyclophosphamide hwolves ALL BUT ONE of the
w Ing. Cl W me... o ,.
a) hydroxylation of 0-4 : 0\ g N/\/ [l' 2
N (V ring opening
0 formation of phosphoramide mustard
d) elimination of acrolein 4
- - - “\_ c clo hos hamide
. Increas c at the N-atorry y p p
C/ (5 5).00mplete hydrolysis andiN-demethylation of cocaine yields ALL BUT ONE of the °‘”'“9 0 OCH3
a) formaldehyde /
b a free hydroxyl on the drug CH3
free ketone carbonyl on the drug @
a» @methanol cocaine 0 ...
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- Spring '08