Unformatted text preview: 16. When partitioned between a mixture of n-octanol and water, drug A’s solubility is
0.6 mglmL in n—octanol and 15 mgl100 mL in water. The value of P for drug A is which of the following: a) 0.004 J 79 is. r/),
b) 0.04 jﬁ It,
C) 0.4 K’s—~49 », i8? ‘. '
e 40 17. Salicylic acid is more readily absorbed from the stomach, than it is reabsorbed by the kidneys. Is this statement true or false? 0H
ﬂ TRUE CE
.1 EDFALSE COOH
salicylic gig 18. Benzo(a)pyrene, a carcinogenic component of cigarette smoke, alkylates the DNA
at which of the following sites? a) MHz-group at the 4-position of cytosine
b) NHz-group at the 6—position of adenine
Hz-group at the 2-position of guanine N-7 of adenine e) N-7 of guanine /C.\ 19. \What is the percentage of the free base form of nicotine at a urinary pH of 6, if the
"xn' tinium ion's pKa = 8? @D99 % ,7
e) 0.99 % i ii!) ‘IDVSLJV. 1.7/5 20. Which of the following rings cannot be found in ciproﬂoxacin?
o ﬁ/Pyridme‘ F COOH b) CYCFGPFUW" [ertquinoline p I
/‘d))iperazine . .
Kvé.’ piperi dine HNd Acnproﬂoxacm 21. Which one of the following drugs requires reductive metabolism for activity? @sulindac ) cyclophosphamide
e) benzylpenicillin ...
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- Spring '08