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2004 5 - 22 Select the best isosteric replacement for the...

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Unformatted text preview: 22. Select the best isosteric replacement for the hydrogen at the 5-position of uracil from the groups listed below: a "-CH3 0 , -\ “13%": HN 5, H 1‘ M [ “’ fails-0H H uracil 23. The higher the logP of a drug, the faster the rate of absorption of a drug from the site of administration. Is this statement true or false? a) IRUE (/15) FALSE 24. The more jglar the drug, the easier it can cross the blood-brain barrier (BBB). Is this statement true or false? _ _ IRUE b) [FALSE \_,/‘ 25. Which of the following statements about drug metabolism is false? .a)“'”’it is carried out mainly in the liver {927“ is localized in the microsomal subcellular fraction c) it makes drugs less polar 11) it makes drugs more water soluble e) it makes drugs more easily excreted by the kidneys 26. Which of the following statement about CYP450 is false? .aklt is a heme—containing enzyme b) it catalyzes the oxidation of drugs (2) its reactions require NADPH d it contains zinc at the active site silt uses molecular oxygen 27. If drug A binds to serum albumin 99%, and if drug B given together displaces 5% of the bound form of drug A how much should the dose of drug A be reduced to have the same therapeutic effect as in the absence of drug B? Q) 2x . b 3x c) 4X d) 5x e) 6X ...
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