Unformatted text preview: 34. After the administration of NaHCOa to a patient overdosed on phenobarbital,
which of the following is responsible for the patient's recovery? a) chemical decomposition of the drug
b; facilitation of the reabsorption of the drug (31361an of the urinary pH
d) acidiﬁcation of the serum e) increased metabolism of the dmg 35. All drug receptors are chiral. True or false? Ca} TRUE b) FALSE 36. The vasoconstrictor octapeptide angiotensin II is produced from its precursor
peptide angiotensin l via hydroiytic cleavage by angiotensin converting enzyme (ACE),
a dipeptidyl carboxypeptidase. How many amino acids make up angiotensin I? a)2 b 6
e) 12 37. The morphine molecule can potentially undergo metabolism at multiple sites.
Which one of the following reactions cannot be responsible for formation of morphine metabolites In the body? -W HO
b) hydrolysis 0
$glucuronidation Ho / NCH3
) sulfation .
morphIne 38. Which one of the following cannot form during the oxidative d_e_allgylat_ion of the
antidepressant Imipramine (Drug-N(CH3)2) to desimipramine? M W :3 I ,or Drug-NHCHa ' O_.
/)\Drug—NHCHO «6’4“ NH—C
fly-'2 imipramine 32H. desimipramine ...
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- Spring '08