MedChem 1st (2002)

MedChem 1st (2002) - Medicinal Chemistry 311 Examination...

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Medicinal Chemistry 311 Name October 1, 2002 Examination #1A Student No. 1. Which of the following drugs is NOT made by plants? a) ephedrine b) caffeine c) digoxin d)streptomycin e) taxol 2. Which of the following is most useful for the extraction of alkaloids? a) distilled water b) dilute base c) dilute acid d) salt water e) octanol 3. Which of the following drugs contain a beta-lactam ring in its structure? a) penicillin b) aspirin c) captopril d) phenobarbital e) sulfanilamide 4. Which of the following drugs contain a thiazolidine ring in its structure? a) penicillin b) aspirin c) captopril d) phenobarbital e) sulfanilamide Which of the following drugs cannot be produced by fish or farm animals? a) vitamin A b) vitamin C c) vitamin D d) porcine insulin e) estrogens 6. Which of the following drugs is NOT produced by microorganisms? a) tetracycline b) penicillin G c) recombinant human insulin d) cephalosporin e) sulfanilamide 7. Which of the following drugs is made by organic chemical synthesis? a) taxol b) chloramphenicol c) reserpine d) morphine e) aspirin
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8. Which of the following processes is suitable for the acquisition of protein therapeutics? a) organic chemical synthesis b) fermentation c) recombinant DNA technology d) large scale extraction from plants e) combinatorial chemistry 9. Which of the following drug class was discovered by Alexander Fleming in 1929? a) penicillins b) sulfonamides c) barbiturates d) cephalosporins e) corticosteroids 10. Which of the following is LEAST likely to be involved in future drug development? a) combinatorial chemistry b) high throughput screening c) rational drug design d) trial and error e) structure-based drug design 11. Which of the following drugs was developed using morphine as a lead? a)benzylpenicillin b) meperidine c) prontosil d) captopril e) sulfamethoxazole 12. Select the best isosteric replacement for the hydrogen at the 5-position of uracil from the groups listed below: H uracil a) -CH3 b) -F c) -Br d) -I e) -OH 13. Drugs A & B bind to the same site on serum albumin in the blood stream. For drug A, the dissociation constant Kd = 2.0 mM ; for drug B, Kd = 0.03 mM. Which of the following statement is FALSE? a) when bound to serum albumin, drugs A & B cannot act at receptors b) drug B binds more strongly to serum albumin than does drug A drug A binds more strongly to serum albumin than does drug B c) when both are present, a large dose of A may significantly increase the activity of B 14. When partitioned between a mixture of n-octanol and water, drug A's solubility is 0.15 mg/mL in
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MedChem 1st (2002) - Medicinal Chemistry 311 Examination...

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